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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3,   Pages 44-56 doi: 10.1016/j.eng.2021.03.029

Abstract:

Organ transplant rejection (OTR) is a complex immune reaction involvingmultiple cells, and it determines graft survival and patient prognosis.However, immunosuppressive agents negatively impact the immune system of the patients, causing them toTherefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejectionThis article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including

Keywords： Immune cells     Innate immune cells     Adaptive immune cells     Organ transplant     Immune tolerance    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theIn the innate immune system, the interactions between pathogen-associated molecular patterns and hostpattern recognition receptors activate multiple signaling pathways in immune cells and induce the productionMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatBesides the main role of immune cells in combating viral infection, the intercellular transfer of pathogen

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.cells that are essential for viral clearance.In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptiveimmune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophagesphagocytosing KIRC cells.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: During natural infection, viral replication is initially controlled by innate immunity before adaptiveimmune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery.Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)in controlling influenza and linking innate and adaptive immune mechanisms, thus making them attractiveWe summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: cells, depends on the balance between numerous activating and inhibitory signals.In addition to the innate direct “killer” functions, NK cell activity contributes to regulateinnate and adaptive immunity (helper or regulator).Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofthe innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblasticMobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticeffect given the importance of the innate immune responses in the elimination of malignant tumors.this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immuneto tumors to mobilize the endogenous immune response.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) haveeffect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immunedatabase (http://clinicaltrials.gov) on registered clinical trials using MSCs to treat a variety of immune

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

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Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 418-424 doi: 10.1007/s11684-013-0297-8

Abstract:

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated acceleratedremains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immunemodulation have been identified, and the pathways behind the immune-mediated destruction of platelets

Keywords： primary immune thrombocytopenia     B lymphocytes     T lymphocytes     antigen-presenting cells     cytokines    

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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: primary response gene 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innateThese studies of TLRs in the innate immune system have implications for the prevention and treatment

Keywords： Toll-like receptors     innate immunity     infectious disease     inflammation    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidlyand directly kill transformed cells in the absence of antigen presensitization.Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK celllines, have been used for producing NK cells.In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsHowever, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associatedwith a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems.

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Review

Bruce R. Blazar

Engineering 2019, Volume 5, Issue 1,   Pages 98-105 doi: 10.1016/j.eng.2018.11.016

Abstract: approaches to prevent and treat graft-versus-host disease (GVHD) are intended to deplete or suppress the T cellshave significant side effects, and may not result in tolerance (i.e., nonresponsiveness) of donor T cellsto conditioning regimen-resistant host alloantigen-bearing cells.As our knowledge of immune system homeostasis has increased, cell populations with immune regulatoryand preclinical proof of concept of GVHD models, along with GVHD outcomes that focus exclusively on immune

Keywords： Graft-versus-host disease (GVHD)     Immune regulatory cells     Cell therapy    

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Title Author Date Type Operation

Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Journal Article

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host

Bruce R. Blazar

Journal Article